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Editorial Reviews

Anthony Quinn and Charles Bronson star in an action-packed Western that explodes with passion, excitement and fiery intensity. Leon Alastray (Quinn), a rebel on the run from the Mexican Army, escapes to the remote village of San Sebastian, where the locals believe he’s a holy man. But when Leon discovers that the area has been devastated by savage Yaqui attacks, he knows he cannot hide the warrior within himself. Revealing his true identity, he leads villagers against the deadly threat, while at the same time battling another enemy: Teclo (Bronson), an antagonist with a shocking secret of his own. As the tension mounts, the people of San Sebastian prepare for an explosive fight to regain their courage...and reclaim their town. SPECIAL FEATURES: Vintage Featurette • Theatrical Trailer.

Guns for San Sebastian

Since Jan 2010, Selleckchem products have been cited in 415 studies from top scientific journals.

Thirteen Nobel Prize winners have published 44 articles with Selleck products.

THE NOBEL PRIZE

Michael Houghton

Won the Nobel Prize in Physiology or Medicine in 2020

James P. Allison

Won the Nobel Prize in Physiology or Medicine in 2018

Michael Rosbash

Won the Nobel Prize in Physiology or Medicine in 2017

Eric Richard Kandel

Won the Nobel Prize in Physiology or Medicine in 2000

Brian K. Kobilka

Won the Nobel Prize in Chemistry in 2012

  • Sci Rep, 2019, 9(1):382

    PubMed: 30674983

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  • Mol Cell, 2019, 75(1):53-65.e7

Robert Lefkowitz

Won the Nobel Prize in Chemistry in 2012

Aaron Ciechanover

Won the Nobel Prize in Chemistry in 2004

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S8938 KGA-2727 SGLT GPCR & G Protein KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 exhibits antidiabetic efficacy in rodent models.
S8939 Mizagliflozin SGLT GPCR & G Protein Mizagliflozin is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation.
S7013 Guadecitabine (SGI-110) Others Others Guadecitabine (SGI-110) is a next-generation hypomethylating agent whose active metabolite decitabine has a longer in-vivo exposure time than intravenous decitabine.
S8812 CM272 DNA Methyltransferase Epigenetics CM-272 is a novel first-in-class dual reversible inhibitor of G9a (GLP) and DNMTs with IC50 of 8 nM, 382 nM, 85 nM, 1200 nM, 2 nM for G9a, DNMT1, DNMT3A, DNMT3B, GLP, respectively. CM-272 prolongs survival in in vivo models of haematological malignancies by at least in part inducing immunogenic cell death.
S9729 Visomitin (SKQ1) Others Others INT-777 (S-EMCA) is a novel potent and selective TGR5 agonist with EC50 values of 0.18 μM, 3.9 μM and 1.45 μM for WT TGR5, TGR5(N76A) and TGR5(Y89F) respectively.
S8500 BAY1125976 Akt PI3K/Akt/mTOR BAY 1125976 is a selective allosteric AKT1/2 inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. BAY1125976 inhibits the activity of AKT1 (IC50 = 5.2 nM at 10 µM ATP and 44 nM at 2 mM ATP) and AKT2 (IC50 = 18 nM at 10 µM ATP and 36 nM at 2 mM ATP) very potently.Whereas BAY1125976 is almost inactive on AKT3 (IC50 = 427 nM at 10 µM ATP).
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Tags: kinase inhibitors, tyrosine kinase inhibitors, enzyme inhibitors, protein inhibitors, proteins kinase inhibitors, small molecules, phosphatase inhibitors